Factors affecting the antimonial treatment duration rate in patients with cutaneous leishmaniasis: survival analysis model
نویسندگان
چکیده مقاله:
Background: Currently, cutaneous leishmaniasis (CL) as a parasitic disease is treated with Glucantime and Pentostam in most of the endemic countries. This study aimed to identify factors affecting the glucantime therapy duration rate in patients with CL using a survival analysis model. Methods: This retrospective descriptive-analytic study was conducted on 1017 CL patients that were referred to the urban and rural comprehensive health centers of Qom Province under the supervision of Qom University of Medical Sciences, Qom, Iran, from April 2014 to March 2019 through the census. The recovery time was measured by the Kaplan-Meier method, and then the survival function was plotted based on each variable. The Log-Rank test was applied to analyze the differences among variables, and after the evaluation of the PH assumption by Shoenfeld residuals, a stepwise forward Cox progressive regression was used to determine factors affecting intralesional or systematic treatment duration in the patients involved with cutaneous leishmaniasis. Results: The recovery rate of lesions in cutaneous leishmaniasis cases was found to be 96.7% by the intralesional treatment and 93% by the systematic one. The mean recovery time for cutaneous leishmaniasis patients was 8.00 weeks for the intralesional treatment and 18.00 days for the systematic treatment. The only significant variable in the intralesional treatment was observed on cases with thigh lesions, meaning that those patients who had CL lesions on their thighs experienced a significant reduction in their recovery time. Furthermore, the lesion variable was also significant (P=0.039) as the recovery chance of those patients who had four or more CL lesions was 30% less. Conclusion: The existence of lesions on CL patients’ thighs and a low number of lesions in CL patients can decrease the recovery time. The use of the Cox regression model in medical studies is more appropriate because not only does it consider the occurrence of the event but also it can reveal the occurrence time of the disease.
منابع مشابه
Antimonial treatment failure rate in patients with cutaneous leishmaniasis
Background: Despite advances in diagnosis and treatment, leishmaniasis is now considered a severe public health problem, particularly in developing countries, such as Iran. Leishmaniasis is among the six most important, parasitic diseases of the world affecting 88 countries in almost every continent. The disease is complex with different clinical presentations such as visceral, cutaneous and mu...
متن کاملModeling Factors Affecting Unemployment Duration Using Survival Analysis
Abstract. In many statistical studies, we are faced with variables such as duration of unemployment, duration of illness to death, the lifespan of a piece, duration of approval of a bill in the parliament, and other similar cases. In such studies, the aim is to find and model the sources that affect the duration of the study period to control the mentioned period by identifying an...
متن کاملRenal function evaluation in patients with American Cutaneous Leishmaniasis after specific treatment with pentavalent antimonial
BACKGROUND Renal evaluation studies are rare in American Cutaneous Leishmaniasis (ACL). The aim of this study is to investigate whether specific treatment reverts ACL-associated renal dysfunction. METHODS A prospective study was conducted with 37 patients with ACL. Urinary concentrating and acidification ability was assessed before and after treatment with pentavalent antimonial. RESULTS Th...
متن کاملClinical and parasite species risk factors for pentavalent antimonial treatment failure in cutaneous leishmaniasis in Peru.
BACKGROUND Treatment for cutaneous leishmaniasis (CL) with standard pentavalent antimonial therapy is hampered by cumbersome administration, toxicity, and potential failure. Knowledge of factors influencing treatment outcome is essential for successful management. METHODS A case-control study of incident cases was performed with patients experiencing their first CL episode. The standard treat...
متن کاملFive-year survival rate and factors affecting the survival of hemodialysis patients
Introduction: Survival rate is important in chronic kidney disease patients due to their dependence on hemodialysis. Therefore, the aim of this study was to evaluate the survival rate of five- years and factors affecting the survival of hemodialysis patients. Materials and Methods: This historical cohort study was performed in 60 hemodialysis patients admitted to Kamyaran Sina Hospital (Iran). ...
متن کاملApplication of Survival Tree Model in Determining Affecting Factors in Breastfeeding Duration
Background and Purpose: Survival tree model is a nonparametric method which can be used to identify the affecting factors from a specific time to the onset of an event. In this method, the categories are selected according to the most important factors. The purpose of this study was to determine the factors affecting the duration of breastfeeding in mothers and introduce the homogeneous subgrou...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ذخیره در منابع من قبلا به منابع من ذحیره شده{@ msg_add @}
عنوان ژورنال
دوره 78 شماره 6
صفحات 388- 396
تاریخ انتشار 2020-09
با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023